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Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …
Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity …
Abstract Poly (ADP-ribose) polymerase (PARP) is considered an essential component in
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …
Therapeutic potential of anticancer activity of nitrogen-containing heterocyclic scaffolds as Janus kinase (JAK) inhibitor: Biological activity, selectivity, and structure …
The JAK-STAT signalling pathway is primarily involved in cytokine signalling and induces
various factors namely, erythropoietin, thrombopoietin, interferons, interleukins, and …
various factors namely, erythropoietin, thrombopoietin, interferons, interleukins, and …
Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships
Cancer is a wide collection of diseases and among the numerous pathways involved in
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies
Cancer is a major societal, public health, and economic burden in the 21 st century, with 9.7
million deaths in 2022 (9.96 million in 2020) and 20 million new cancer cases (19.6 million …
million deaths in 2022 (9.96 million in 2020) and 20 million new cancer cases (19.6 million …
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents
Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined
for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant …
for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant …
Design, synthesis of 1, 2, 4-triazine derivatives as antidepressant and antioxidant agents: In vitro, in vivo and in silico studies
The novel series of substituted-N-(5, 6-diphenyl-1, 2, 4-triazin-3-yl) benzamides (R: 1–12)
were designed, synthesized and evaluated for in-vitro and in-vivo antidepressant-like …
were designed, synthesized and evaluated for in-vitro and in-vivo antidepressant-like …
Advancement of DDR1 and DDR2 Inhibitors: Therapeutic Potential of Bioactive Compounds, Designing Strategies, and Structure‐Activity Relationship (SAR)
DDR1 and DDR2 are nonintegrin collagen receptors in the receptor tyrosine kinase family.
Both DDRs bind to various collagen types and perform crucial functions in embryo …
Both DDRs bind to various collagen types and perform crucial functions in embryo …
Synthesis of Novel Triazine-Based Chalcones and 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as Potential Leads in the Search of Anticancer, Antibacterial and …
This study presents the synthesis of four series of novel hybrid chalcones (20, 21) a–g and
(23, 24) a–g and six series of 1, 3, 5-triazine-based pyrimido [4, 5-b][1, 4] diazepines (28–33) …
(23, 24) a–g and six series of 1, 3, 5-triazine-based pyrimido [4, 5-b][1, 4] diazepines (28–33) …
Design, synthesis, and pharmacological evaluation of aryl oxadiazole linked 1, 2, 4-triazine derivatives as anticonvulsant agents
A series of new clubbed aryl oxadiazole-1, 2, 4-triazine derivatives (6a-l) were designed and
synthesized using appropriate chemical routes. The structures were designed to have the …
synthesized using appropriate chemical routes. The structures were designed to have the …