R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …

Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA
damage signaling and repair within chromatin. In this study, we report the identification of …

Altered epigenetic reprogramming contributes to breast cancer progression and metastasis.
How the epigenetic reader mediates breast cancer progression remains poorly understood …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new
therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

The transformed state in acute leukemia requires gene regulatory programs involving
transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D …

The ability of transcription factors to discriminate between different classes of binding sites
associated with specific biological functions underpins effective gene regulation in …