Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …

How can the genome of Drosophila melanogaster contain fewer genes than the
undoubtedly simpler organism Caenorhabditis elegans? The answer must lie within their …

Assembling a comprehensive catalog of common human sequence polymorphisms is a key
goal of the Human Genome Project. The International SNP Map Working Group has …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

A remaining challenge for the human genome project involves the identification and
annotation of expressed genes. The public and private sequencing efforts have identified∼ …

The most important product of the sequencing of a genome is a complete, accurate
catalogue of genes and their products, primarily messenger RNA transcripts and their …

A crucial aim upon the completion of the human genome is the verification and functional
annotation of all predicted genes and their protein products. Here we describe the map** …

A DNA microarray representing nearly all of the unique sequences of human Chromosome
22 was constructed and used to measure global-transcriptional activity in placental poly (A)+ …

We have generated 36,991,173 17-base sequence “signatures” representing transcripts
from the model plant Arabidopsis. These data were derived by massively parallel signature …