Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …

Abstract How N 6-methyladenosine (m6A), the most abundant mRNA modification,
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The FOX family of transcription factors was originally identified in 1989, comprising the
FOXA to FOXS subfamilies. FOXO3, a well-known member of the FOXO subfamily, is widely …

Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized as a
distinct disease from sarcopenia and is directly related to declining muscle capacity. Hence …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

The high prevalence of sarcopenia in an aging population has an underestimated impact on
quality of life by increasing the risk of falls and subsequent hospitalization. Unfortunately, the …