The research field of systems biology has greatly advanced and, as a result, the concept of
network pharmacology has been developed. This advancement, in turn, has shifted the …

The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

Background & Aims Genome-wide association studies (GWASs) have associated
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …

Cancer is characterized by gene expression aberrations. Studies have largely focused on
coding sequences and promoters, even though distal regulatory elements play a central role …

Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …

Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …

We performed a meta-analysis of five genome-wide association studies to identify common
variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 …

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and
common genetic variants that contribute to familial risk. Here we report the results of a two …