Recombination-based tools for introducing targeted genomic mutations in Mycobacterium
tuberculosis are not efficient due to higher rate of illegitimate recombination compared with …

Chaperonins are a class of molecular chaperones that assemble into a large double ring
architecture with each ring constituting seven to nine subunits and enclosing a cavity for …

Molecular chaperones and protein folding catalysts are normally thought of as intracellular
proteins involved in protein folding quality control. However, in the mycobacteria there is …

Background Tuberculosis is an infectious bacterial disease in humans caused primarily by
Mycobacterium tuberculosis, and infects one-third of the world's total population …

Vibrio anguillarum is a major pathogenic bacterium that causes vibriosis and septicemia in
fish and shellfish. In this study, we identified the groESL genes, which encode bacterial …

Mycobacterium smegmatis contains three chaperonin (cpn60) genes homologous to the
Escherichia coli groEL gene. One of these (cpn60. 1) is required for biofilm formation, but is …

Threonylcarbamoyladenosine is a universally conserved essential modification of tRNA that
ensures translational fidelity in cellular milieu. TsaD, TsaB and TsaE are identified as tRNA …

The transcription from rrn and a number of other promoters is regulated by initiating
ribonucleotides (iNTPs) and guanosine tetra/penta phosphate [(p) ppGpp], either by …

The success of Mycobacterium tuberculosis depends on its ability to withstand and survive
the hazardous environment inside the macrophages that are created by reactive oxygen …

Aim The current study aims to understand the role of HrcA in stress response of M.
tuberculosis. Methods and Results In this study, using an hrcA knock out mutant of M …