[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation
Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization
Impulse propagation in biological tissues is known to be modulated by structural
heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity …
heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity …
Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4. 3 potassium channel and Brugada syndrome
JR Giudicessi, D Ye, DJ Tester, L Crotti, A Mugione… - Heart rhythm, 2011 - Elsevier
BACKGROUND: Brugada syndrome (BrS) is a sudden death–predisposing genetic
condition characterized electrocardiographically by ST segment elevation in the leads V1 …
condition characterized electrocardiographically by ST segment elevation in the leads V1 …
Myokit: a simple interface to cardiac cellular electrophysiology
Myokit is a new powerful and versatile software tool for modeling and simulation of cardiac
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …