Syndecans–key regulators of cell signaling and biological functions
Syndecans are a small family of four transmembrane proteoglycans in mammals. They have
similar structural organization, consisting of an N‐terminal ectodomain, single …
similar structural organization, consisting of an N‐terminal ectodomain, single …
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …
neurodegenerative movement disorder. No cure is available that would stop the …
Biology of GDNF and its receptors—relevance for disorders of the central nervous system
CF Ibáñez, JO Andressoo - Neurobiology of disease, 2017 - Elsevier
A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …
Therapeutic potential of neurotrophins for repair after brain injury: a hel** hand from biomaterials
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …
in recovery. Significant effort has been made to try and minimize neuronal damage following …
GDNF synthesis, signaling, and retrograde transport in motor neurons
AF Cintrón-Colón, G Almeida-Alves, AM Boynton… - Cell and tissue …, 2020 - Springer
Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …
Unconventional neurotrophic factors CDNF and MANF: structure, physiological functions and therapeutic potential
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived
neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which …
neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which …
GDNF and Parkinson's disease: where next? A summary from a recent workshop
The concept of repairing the brain with growth factors has been pursued for many years in a
variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using …
variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using …
GDNF, a neuron-derived factor upregulated in glial cells during disease
M Duarte Azevedo, S Sander… - Journal of clinical medicine, 2020 - mdpi.com
In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively
expressed by neurons, and, in some instances, it has also been shown to derive from a …
expressed by neurons, and, in some instances, it has also been shown to derive from a …
Cellular and molecular mechanisms controlling the migration of neocortical interneurons
O Marín - European Journal of Neuroscience, 2013 - Wiley Online Library
The discovery, approximately 15 years ago, that cortical GABA ergic interneurons originate
outside the pallium has revolutionized our understanding of the development of the cerebral …
outside the pallium has revolutionized our understanding of the development of the cerebral …
Proteoglycans and their roles in brain cancer
Glioblastoma, a malignant brain cancer, is characterized by abnormal activation of receptor
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …