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Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
Restriction factors: from intrinsic viral restriction to sha** cellular immunity against HIV-1
M Colomer-Lluch, A Ruiz, A Moris… - Frontiers in …, 2018 - frontiersin.org
Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …
blocking viral replication and propagation. In addition to interfering at critical steps of the …
Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins
Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …
Interferon resistance of emerging SARS-CoV-2 variants
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and
resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic …
resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic …
Interferon‐based treatment of chronic hepatitis D
Abstract Treatment of hepatitis D virus (HDV) infection has been based on the administration
of interferon‐alfa for more than three decades. First studies to treat HDV‐infected patients …
of interferon‐alfa for more than three decades. First studies to treat HDV‐infected patients …
Type I interferon signaling, regulation and gene stimulation in chronic virus infection
Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …
infections, from the establishment of an antiviral state to invoking and regulating innate and …
[HTML][HTML] Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
Interferon lambda genetics and biology in regulation of viral control
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …
Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness
Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the
donor quasispecies establishing the new infection. A critical, and as yet unresolved …
donor quasispecies establishing the new infection. A critical, and as yet unresolved …
[HTML][HTML] Herpes simplex virus type 1 interactions with the interferon system
K Danastas, M Miranda-Saksena… - International journal of …, 2020 - mdpi.com
The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …