The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Chronic stress is common among cancer patients due to the psychological, operative, or
pharmaceutical stressors at the time of diagnosis or during the treatment of cancers. The …

Doxorubicin is limited in its therapeutic utility due to its life-threatening cardiovascular side
effects. Here, we present an integrated drug discovery pipeline combining human induced …

Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an
epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer …

Background The metabolic enzyme carbonic anhydrase 12 (CA12/CAXII) emerges as a
promising cancer therapeutic target with drug development projects underway. Previous …

Tumor-associated carbonic anhydrases IX (CAIX) and XII (CAXII) have long been in the
spotlight as potential new targets for anti-cancer therapy. Recently, CAIX/CAXII specific …

The inversion of the pH gradient in malignant tumors, known as the pH paradigm, is
increasingly becoming accepted by the scientific community as a hallmark of cancer …

Intrinsic or acquired resistance to chemotherapy is a major hurdle in the treatment of cancer.
One of the key mechanisms of resistance is the overexpression of the drug efflux transporter …

Over the last few years, much attention has been paid to phytocannabinoids derived from
Cannabis for their therapeutic potential. Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol …

Background: Despite the development of numerous customized techniques for treating
breast cancer, cancer patients' clinical results revealed adverse consequences in addition to …