Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Senescent cells remain metabolically active, but their metabolic landscape and resulting
implications remain underexplored. Here, we report upregulation of pyruvate …

Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and
proliferation leading to the degeneration of cellular structure and function, has been …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …