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Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …
analysis has become a powerful tool for exploration of cellular networks and dysregulated …
Coordinated immune cell networks in the bone marrow microenvironment define the graft versus leukemia response with adoptive cellular therapy
Donor lymphocyte infusion (DLI) is an established therapy for relapsed acute myeloid
leukemia (AML) after hematopoietic stem cell transplant (HSCT), but response rates are …
leukemia (AML) after hematopoietic stem cell transplant (HSCT), but response rates are …
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy
Understanding how intratumoral immune populations coordinate antitumor responses after
therapy can guide treatment prioritization. We systematically analyzed an established …
therapy can guide treatment prioritization. We systematically analyzed an established …
T cell receptor–centric perspective to multimodal single-cell data analysis
The T cell receptor (TCR), despite its importance, is underutilized in single-cell analysis, with
gene expression features solely driving current strategies. Here, we argue for a TCR-first …
gene expression features solely driving current strategies. Here, we argue for a TCR-first …
Single cell RNA-sequencing of feline peripheral immune cells with V (D) J repertoire and cross species analysis of T lymphocytes
Introduction The domestic cat (Felis catus) is a valued companion animal and a model for
virally induced cancers and immunodeficiencies. However, species-specific limitations such …
virally induced cancers and immunodeficiencies. However, species-specific limitations such …
[HTML][HTML] Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells
Gamma delta T cells play a crucial role in anti-tumor immunity due to their cytotoxic
properties. However, the role and extent of γδ T cells in production of pro-tumorigenic …
properties. However, the role and extent of γδ T cells in production of pro-tumorigenic …
STEGO. R: an application to aid in scRNA-seq and scTCR-seq processing and analysis
Introduction The hypervariable T cell receptor (TCR), created through somatic
recombination, allows for recognition of a diverse array of antigens. Single sequencing …
recombination, allows for recognition of a diverse array of antigens. Single sequencing …
IMMClock reveals immune aging and T cell function at single-cell resolution
The aging of the immune system substantially impacts individual immune responses, yet
accurately quantifying immune age remains a complex challenge. Here we developed …
accurately quantifying immune age remains a complex challenge. Here we developed …
Multi-omic single-cell integration for understanding T cell responses in Acute Myeloid Leukemia
P Desai - 2024 - digitalcommons.library.tmc.edu
In recent years, translational initiatives have gained significant traction within the medical
community. Clinical parameters alone have been insufficient to fully understand the intricate …
community. Clinical parameters alone have been insufficient to fully understand the intricate …
Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
H Banks - 2025 - repository.cam.ac.uk
Inflammatory bowel disease (IBD) is an umbrella term for disorders involving chronic
inflammation of the gastrointestinal tract, with over 6 million cases reported worldwide. 320 …
inflammation of the gastrointestinal tract, with over 6 million cases reported worldwide. 320 …