Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE,
humans) are an emerging behavioral intervention approach based on the understanding of …

Molecular clocks are present in almost every cell to anticipate daily recurring and
predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions …

Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …

Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans …

The calorie restriction paradigm has provided one of the most widely used and most useful
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …

Understanding aging is a key biological goal. Precision gerontology aims to predict how
long individuals will live under different treatment scenarios. Calorie and protein restriction …

Caloric restriction is a robust intervention to increase lifespan. Giving less food (calorie
restriction [CR]) or allowing free access to a diluted diet with indigestible components …

Dietary restriction (DR) is the most consistent environmental manipulation to extend lifespan.
Originally thought to be caused by a reduction in caloric intake, recent evidence suggests …

The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on
lifespan fails to explain why CR generates negative impacts alongside the positive effects …