The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Scorpion toxins have been the subject of many studies exploring their pharmacological
potential. The high affinity and the overall selectivity to various types of ionic channels …

The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes
(hiPSC-CMs) is a major limitation to the use of these valuable cells for pre-clinical toxicity …

Although beat-to-beat variability (short-term variability, SV) of action potential duration (APD)
is considered as a predictor of imminent cardiac arrhythmias, the underlying mechanisms …

To improve proarrhythmic predictability of preclinical models, we assessed whether human
ventricular-like embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be selected …

Proarrhythmia, the development of new or worse arrhythmias in response to drug therapy, is
a major limitation to the development and use of new drugs. There are different types of drug …

The successful development of novel drugs requires the ability to detect (and avoid)
compounds that may provoke Torsades-de-Pointes (TdeP) arrhythmia while endorsing …

INTRODUCTION: Accumulating evidence suggest that drug-induced QT prolongation per se
poorly predicts repolarisation-related proarrhythmia liability. We examined whether beat-by …

Background Enhanced dispersion of action potential duration (APD) is a major contributor to
long QT syndrome (LQTS)-related arrhythmias. Objective To investigate spatial correlations …

Background and purpose: Evaluation of the potential for delayed ventricular repolarization
and proarrhythmia by new drugs is essential. We investigated if dog left ventricular …