Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …

Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …

Colorectal cancer arises through a gradual series of histological changes, each of which is
accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply …

Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or-
independent signaling has been detected in many types of human cancer, but the …

Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

The Bacteroides fragilis (B. fragilis) produce biofilm for colonisation in the intestinal tract can
cause a series of inflammatory reactions due to B. fragilis toxin (BFT) which can lead to …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …