The prevalence of obesity is rapidly increasing globally. Epidemiological studies have
associated obesity with a range of cancer types, although the mechanisms by which obesity …

Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in
incidence in developed countries. The emergence of hepatitis C virus (HCV) accounts for …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

B. Kidney C. Other tissues D. Extracellular insulin degradation III. Cellular Insulin Uptake IV.
Cellular Insulin Degradation A. Degradation products B. Assay for insulin degradation C …

Background The positive association between obesity and postmenopausal breast cancer
has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is …

Biguanides have been developed for the treatment of hyperglycemia and type 2 diabetes.
Recently, metformin, the most widely prescribed biguanide, has emerged as a potential …

This article reviews the biology, prevalence and risks for obesity in people and companion
dogs and cats, and explores the links between obesity and diabetes mellitus and cancer …

There is evidence, both in vitro and in vivo, that receptor tyrosine kinases play a key role in
the formation and progression of human cancer. In particular, the insulin-like growth factor …

Excess adiposity is a risk factor for several cancers of the gastrointestinal system, specifically
oesophageal adenocarcinoma and colorectal, small intestine, pancreatic, liver, gallbladder …

Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …