Central sensitivity syndromes are characterized by distressing symptoms, such as pain and
fatigue, in the absence of clinically obvious pathology. The scientific underpinnings of these …

This article provides an illustrative overview of neurophysiological changes related to acute
and chronic pain involving structural and functional brain changes, which might be the …

Background Previous studies have repeatedly found distinct brain morphometric changes in
patients with fibromyalgia (FM), mainly affecting gray and white matter abnormalities in …

Low back pain (LBP) is an important medical and socioeconomic problem. Impaired
sensorimotor control has been suggested to be a likely mechanism underlying development …

Pain can be elicited through all mammalian sensory pathways yet cross-modal sensory
integration, and its relationship to clinical pain, is largely unexplored. Centralized chronic …

Fibromyalgia is a chronic pain syndrome, characterized by widespread musculoskeletal
pain with diffuse tenderness at multiple tender points. Despite intense investigations, the …

Cognitive and behavioral impairments are core manifestations of fibromyalgia and may be
more disabling than pain itself. Involvement of the central nervous system is ascertained by …

Fibromyalgia is characterized by chronic widespread pain and several additional symptoms
such as fatigue, cognitive dysfunction, depressive episodes, and anxiety. The underlying …

Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety
and depression after pain chronification reportedly are caused by brain remodeling …

The perceived lack of control over the experience of pain is arguably-one major cause of
agony and impaired life quality in patients with chronic pain disorders as fibromyalgia (FM) …