WNT signaling in cardiac and vascular disease
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
Scalable stirred-suspension bioreactor culture of human pluripotent stem cells
DE Kehoe, D **g, LT Lock… - Tissue Engineering Part …, 2010 - liebertpub.com
Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …
cell types for therapies against devastating diseases. However, a prerequisite for realizing …
Wnt activation and reduced cell-cell contact synergistically induce massive expansion of functional human iPSC-derived cardiomyocytes
Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size
The Hippo signaling pathway regulates growth of the heart and other tissues. Hippo
pathway kinases influence the activity of various targets, including the transcriptional …
pathway kinases influence the activity of various targets, including the transcriptional …
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …
proliferation, although this capacity markedly diminishes after the first week of life …
[HTML][HTML] A neonatal blueprint for cardiac regeneration
Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …
compromises cardiac function and contributes to the ongoing burden of heart failure. In …
Transcriptional landscape of cardiomyocyte maturation
Decades of progress in developmental cardiology has advanced our understanding of the
early aspects of heart development, including cardiomyocyte (CM) differentiation. However …
early aspects of heart development, including cardiomyocyte (CM) differentiation. However …
Cardiomyocytes cellular phenotypes after myocardial infarction
Despite the increasing success of interventional coronary reperfusion strategies, mortality
related to acute myocardial infarction (MI) is still substantial. MI is defined as sudden death …
related to acute myocardial infarction (MI) is still substantial. MI is defined as sudden death …
Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal
ED Cohen, Y Tian, EE Morrisey - 2008 - journals.biologists.com
Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular
biology (including cardiac morphogenesis, and the self-renewal and differentiation of …
biology (including cardiac morphogenesis, and the self-renewal and differentiation of …
[HTML][HTML] Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation
Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …