Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

A great variety of systems in nature, society and technology–from the web of sexual contacts
to the Internet, from the nervous system to power grids–can be modeled as graphs of …

Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …

The power of any kind of network approach lies in the ability to simplify a complex system so
that one can better understand its function as a whole. Sometimes it is beneficial, however …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Precision medicine relies on validated biomarkers with which to better classify patients by
their probable disease risk, prognosis and/or response to treatment. Although …

ConsensusPathDB consists of a comprehensive collection of human (as well as mouse and
yeast) molecular interaction data integrated from 32 different public repositories and a web …