Artificial intelligence in cancer target identification and drug discovery
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …
novel drugs from biology networks because the networks can effectively preserve and …
Biomarker development in the precision medicine era: lung cancer as a case study
Precision medicine relies on validated biomarkers with which to better classify patients by
their probable disease risk, prognosis and/or response to treatment. Although …
their probable disease risk, prognosis and/or response to treatment. Although …
A protein interaction landscape of breast cancer
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
The functional impact of alternative splicing in cancer
Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …
recognized as important signatures for tumor progression and therapy. However, their …
Modern temporal network theory: a colloquium
The power of any kind of network approach lies in the ability to simplify a complex system so
that one can better understand its function as a whole. Sometimes it is beneficial, however …
that one can better understand its function as a whole. Sometimes it is beneficial, however …
Analyzing and interpreting genome data at the network level with ConsensusPathDB
ConsensusPathDB consists of a comprehensive collection of human (as well as mouse and
yeast) molecular interaction data integrated from 32 different public repositories and a web …
yeast) molecular interaction data integrated from 32 different public repositories and a web …
The BioGRID interaction database: 2015 update
A Chatr-Aryamontri, BJ Breitkreutz… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …
http://thebiogrid. org) is an open access database that houses genetic and protein …
Temporal networks
A great variety of systems in nature, society and technology–from the web of sexual contacts
to the Internet, from the nervous system to power grids–can be modeled as graphs of …
to the Internet, from the nervous system to power grids–can be modeled as graphs of …
Network medicine: a network-based approach to human disease
Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
[HTML][HTML] Interactome networks and human disease
Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …
phenotype relationships. Here, we review basic concepts in network biology, discussing …