[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …
and destructive potentials. It can exert opposing actions triggering either neuron survival …
Heterogeneity and specialized functions of translation machinery: from genes to organisms
NR Genuth, M Barna - Nature Reviews Genetics, 2018 - nature.com
Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …
abundance of proteins made from individual gene products in cells, tissues and organisms …
Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
Persistent nociceptor hyperactivity as a painful evolutionary adaptation
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets
SRA Alles, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …
neurons is imperative for the development and persistence of many forms of neuropathic …
The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the
drug has many mechanisms of action, most of these converge on AMP activated protein …
drug has many mechanisms of action, most of these converge on AMP activated protein …
Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging
stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of …
stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of …
Translational control mechanisms in persistent pain
Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …
Cognition in the chronic pain experience: Preclinical insights
Acutely, pain is protective. It promotes escape from, and future avoidance of, noxious stimuli
through strong and often lifetime associative memories. However, with persistent acute pain …
through strong and often lifetime associative memories. However, with persistent acute pain …
Type I interferons act directly on nociceptors to produce pain sensitization: implications for viral infection-induced pain
One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …