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Oxidative stress and antioxidants in neurodegenerative disorders
EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …
with significant public health importance. The pathophysiology of neurodegenerative …
Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs
AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …
affect millions of people worldwide, with both prevalence and incidence increasing with age …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications
Z Liu, T Zhou, AC Ziegler, P Dimitrion… - Oxidative medicine and …, 2017 - Wiley Online Library
Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative
disorders. These diseases are normally characterized by progressive loss of neuron cells …
disorders. These diseases are normally characterized by progressive loss of neuron cells …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
Oxidative stress and the central nervous system
S Salim - The Journal of pharmacology and experimental …, 2017 - Elsevier
Biochemical integrity of the brain is vital for normal functioning of the central nervous system
(CNS). One of the factors contributing to cerebral biochemical impairment is a chemical …
(CNS). One of the factors contributing to cerebral biochemical impairment is a chemical …
Clusterin in Alzheimer's disease: mechanisms, genetics, and lessons from other pathologies
EM Foster, A Dangla-Valls, S Lovestone… - Frontiers in …, 2019 - frontiersin.org
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
Antioxidants in Alzheimer's disease: Current therapeutic significance and future prospects
P Pritam, R Deka, A Bhardwaj, R Srivastava, D Kumar… - Biology, 2022 - mdpi.com
Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …
intensifying impairments in cognition, behavior, and memory. Histopathological AD …
Regulation of pyruvate metabolism and human disease
LR Gray, SC Tompkins, EB Taylor - Cellular and molecular life sciences, 2014 - Springer
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …