High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

Mutational activation of KRAS promotes the initiation and progression of cancers, especially
in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific …

Meiotic recombination commences with hundreds of programmed DNA breaks; however, the
degree to which they are accurately repaired remains poorly understood. We report that …

Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create
multiple genetic changes in a single event. Activity of A3s results in striking 'mutation …

Cancer genome sequencing has revealed that somatic mutation rates vary substantially
across the human genome and at scales from megabase-sized domains to individual …

Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and
breaks on metaphase chromosomes under replication stress. They are hotspots for …

Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse
underlying mutagenic mechanisms that shape cancer genomes are not understood. This …

Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that
primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of …