The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions
encompassing the NF1 gene and its flanking regions (NF1 microdeletions). The majority of …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

Emerging studies document the roles of long non-coding RNAs (LncRNAs) in regulating
gene expression at chromatin level but relatively less is known how they regulate DNA …

Resistance to Herceptin represents a significant challenge for successful treatment of HER2-
positive breast cancer. Here, we show that in Herceptin-sensitive cells, FOXO3a regulates …

The metastatic cascade is a complex and multistep process with many potential barriers.
Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and …

Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the
discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 (YY1) …

Yin Yang‐1 (YY1) is a zinc finger protein and member of the GLI‐Kruppel family that can
activate or inactivate gene expression depending on interacting partners, promoter context …

Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …

Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …

Skeletal muscle differentiation is orchestrated by a network of transcription factors,
epigenetic regulators, and non‐coding RNAs. The transcription factor Yin Yang 1 (YY1) …