Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

The myelin sheath is an essential, multilayered membrane structure that insulates axons,
enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein …

Lateral organization in the plane of the plasma membrane is an important driver of biological
processes. The past dozen years have seen increasing experimental support for the notion …

The plasma membrane (PM) is a highly heterogenous structure intertwined with the cortical
actin cytoskeleton and extracellular matrix. This complex architecture makes it difficult to …

The organelles of eukaryotic cells maintain distinct protein and lipid compositions required
for their specific functions. The mechanisms by which many of these components are sorted …

Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in
peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane …

This review considers the following hypotheses, some well‐supported and some
speculative. Almost all of the sterol molecules in plasma membranes are associated with …

The MAL gene encodes a 17-kDa protein containing four putative transmembrane segments
whose expression is restricted to human T cells, polarized epithelial cells and myelin …