Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

The supply of oxygen and nutrients to tissues is performed by the blood system and involves
a net leakage of fluid outward at the capillary level. One of the principal functions of the …

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …

Biophysical and biochemical cues work in concert to regulate angiogenesis. These cues
guide angiogenesis during development and wound healing. Abnormal cues contribute to …

Favouring or thwarting the development of a vascular network is essential in fields as
diverse as oncology, cardiovascular disease or tissue engineering. As a result …

Physical cues have emerged as critical influencers of cell function during physiological
processes, like development and organogenesis, and throughout pathological …

Sprouting angiogenesis, the formation of new vessels from preexisting vasculature, is an
essential process in the regeneration of new tissues as well as in the development of some …

Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

We previously identified CLEC14A as a tumour endothelial marker. Here we show that
CLEC14A is a regulator of sprouting angiogenesis in vitro and in vivo. Using a human …

Endothelial cells (ECs) integrate signals from the local microenvironment to guide their
behaviour. RhoA is involved in vascular endothelial growth factor (VEGF)-driven …