The study of host–pathogen interactions has illuminated fundamental research avenues in
both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable …

Simple Summary Inflammation is a central part of the body's response to harm that can be
elicited by microbes, environmental factors, or internal injuries. This complex physiological …

The intestinal microbiota influences the development and function of myeloid lineages such
as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic …

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In
chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive …

Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses
to danger stimuli and infection, and their dysregulation is associated with an increasing …

In recent years, Dictyostelium discoideum has become an important model organism to
study the cell biology of professional phagocytes. This amoeba not only shares many …

During development, inflammation or tissue injury, macrophages may successively engulf
and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis. How …

Increasing numbers of studies seek to characterize the different cellular sub-populations
present in mammalian tissues. The techniques “Isolation of Nuclei Tagged in Specific Cell …

Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An
elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated …

The zebrafish is now an important model organism for cancer biology studies and provides
unique and complementary opportunities in comparison to the mammalian equivalent. The …