The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Role of m6A writers, erasers and readers in cancer
Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
Pocketflow is a data-and-knowledge-driven structure-based molecular generative model
Y Jiang, G Zhang, J You, H Zhang, R Yao… - Nature Machine …, 2024 - nature.com
Deep learning-based molecular generation has extensive applications in many fields,
particularly drug discovery. However, the majority of current deep generative models are …
particularly drug discovery. However, the majority of current deep generative models are …
Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins
J Liao, Y Wei, J Liang, J Wen, X Chen, B Zhang… - Cell death …, 2022 - nature.com
Abstract YT521-B homology (YTH) domain-containing proteins (YTHDF1-3, YTHDC1-2) are
the most crucial part of N6-methyladenosine (m6A) readers and play a regulatory role in …
the most crucial part of N6-methyladenosine (m6A) readers and play a regulatory role in …
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
Y Cheng, Z Gao, T Zhang, Y Wang, X **e, G Han, Y Li… - Cell Stem Cell, 2023 - cell.com
Summary N 6-methyladenosine (m 6 A) is a common chemical modification for mammalian
mRNA and exhibits high dynamics in various biological processes. However, dynamics of m …
mRNA and exhibits high dynamics in various biological processes. However, dynamics of m …
[HTML][HTML] RNA N6-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer
Abstract RNA N 6-methyladenosine (m 6 A) modification and its regulators fine tune gene
expression and contribute to tumorigenesis. This study aims to uncover the essential role …
expression and contribute to tumorigenesis. This study aims to uncover the essential role …
Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
H Yan, L Zhang, X Cui, S Zheng, R Li - Cell Death Discovery, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a key area in Epigenetics and has been increasingly
focused these years. In the m6A process, readers recognize the m6A modification on …
focused these years. In the m6A process, readers recognize the m6A modification on …
The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression
YG Hong, Z Yang, Y Chen, T Liu, Y Zheng, C Zhou… - Cancer research, 2023 - AACR
Abstract N6-methyladenosine (m6A), the most abundant modification in mRNAs, has been
defined as a crucial modulator in the progression of acute myelogenous leukemia (AML) …
defined as a crucial modulator in the progression of acute myelogenous leukemia (AML) …