Immune response following traumatic spinal cord injury: Pathophysiology and therapies
RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T
The timing of flowering affects the success of sexual reproduction. This developmental event
also determines crop yield, biomass, and longevity. Therefore, this mechanism has been …
also determines crop yield, biomass, and longevity. Therefore, this mechanism has been …
Acute spinal cord injury: Pathophysiology and pharmacological intervention
Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
Developments of CRBN-based PROTACs as potential therapeutic agents
C Wang, Y Zhang, Y Wu, D **ng - European journal of medicinal chemistry, 2021 - Elsevier
Protease-targeted chimeras (PROTACs) are a new technology that is receiving much
attention in the treatment of diseases. The mechanism is to inhibit protein function by …
attention in the treatment of diseases. The mechanism is to inhibit protein function by …
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
E Spiekerkoetter, X Tian, J Cai, RK Hopper… - The Journal of clinical …, 2013 - jci.org
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the
pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high …
pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high …
Gene therapy tools for brain diseases
Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …
understood. Many of these disorders lack a cure and are seeking more specific and effective …
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
Calcineurin inhibitors (CNIs) are immunosuppressive drugs that are used widely to prevent
rejection of transplanted organs and to treat autoimmune disease. Hypertension and renal …
rejection of transplanted organs and to treat autoimmune disease. Hypertension and renal …
Oligodendrocytes support axonal transport and maintenance via exosome secretion
C Frühbeis, WP Kuo-Elsner, C Müller, K Barth… - PLoS …, 2020 - journals.plos.org
Neurons extend long axons that require maintenance and are susceptible to degeneration.
Long-term integrity of axons depends on intrinsic mechanisms including axonal transport …
Long-term integrity of axons depends on intrinsic mechanisms including axonal transport …
[HTML][HTML] The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506
Recent research has shown that Coronavirus (CoV) replication depends on active
immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited …
immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited …