Tumor biomarkers for diagnosis, prognosis and targeted therapy

Y Zhou, L Tao, J Qiu, J Xu, X Yang, Y Zhang… - Signal transduction and …, 2024 - nature.com
Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

J Yang, R Xu, C Wang, J Qiu, B Ren… - Cancer …, 2021 - Wiley Online Library
Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …

Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Glycosylation: mechanisms, biological functions and clinical implications

M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Artificial intelligence in pancreatic cancer

B Huang, H Huang, S Zhang, D Zhang, Q Shi… - …, 2022 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer is the deadliest disease, with a five-year overall survival rate of just 11%.
The pancreatic cancer patients diagnosed with early screening have a median overall …

[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Dual starvations induce pyroptosis for orthotopic pancreatic cancer therapy through simultaneous deprivation of glucose and glutamine

X Wang, B Ding, W Liu, L Qi, J Li, X Zheng… - Journal of the …, 2024 - ACS Publications
Pancreatic cancer is a highly fatal disease, and existing treatment methods are ineffective,
so it is urgent to develop new effective treatment strategies. The high dependence of …

Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal transduction and targeted therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

[HTML][HTML] Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review

C Nie, I Shaw, C Chen - Journal of Pharmaceutical Analysis, 2023 - Elsevier
With the continuous discovery and research of predictive cancer-related biomarkers, liquid
biopsy shows great potential in cancer diagnosis. Surface-enhanced Raman scattering …

[HTML][HTML] Circulating microRNAs as potential biomarkers in pancreatic cancer—advances and challenges

AA Seyhan - International journal of molecular sciences, 2023 - mdpi.com
There is an urgent unmet need for robust and reliable biomarkers for early diagnosis,
prognosis, and prediction of response to specific treatments of many aggressive and deadly …