Elevated impulsivity is a symptom shared by various psychiatric disorders such as
substance use disorder, bipolar disorder, and attention-deficit/hyperactivity disorder …

Highlights•'Liking'and 'wanting'are important components of positive affect.•Neural hyper-
reactivity of 'wanting'brain systems can lead to addiction via incentive-sensitization and …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

Background The balance between goal-directed behavior and habits has been
hypothesized to be biased toward the latter in individuals with cocaine use disorder (CUD) …

Conventional monoamine-based pharmacotherapy, considered the first-line treatment for
major depressive disorder (MDD), has several challenges, including high rates of non …

Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in
stress and reward processing, both crucially impaired in addictive disorders. Preclinical …

Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide
health problems. To date, there are no FDA-approved medications for the treatment of these …

Substance use disorder (SUD) is a chronic brain condition, with compulsive and
uncontrollable drug-seeking that leads to long-lasting and harmful consequences. The …

Substance use disorders (SUD) can lead to serious health problems, and there is a great
interest in develo** new treatment methods to alleviate the impact of substance abuse. In …

Impulse-control disorders are commonly observed during dopamine-replacement therapy in
Parkinson's disease, but the majority of patients seems “immune” to this side effect …