State-of-the-art strategies for targeting the DNA damage response in cancer

PG Pilié, C Tang, GB Mills, TA Yap - Nature reviews Clinical oncology, 2019 - nature.com
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

C Tomasetti, L Li, B Vogelstein - Science, 2017 - science.org
Cancers are caused by mutations that may be inherited, induced by environmental factors,
or result from DNA replication errors (R). We studied the relationship between the number of …

[HTML][HTML] The molecular taxonomy of primary prostate cancer

A Abeshouse, J Ahn, R Akbani, A Ally, S Amin… - Cell, 2015 - cell.com
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

S Thakkar, D Sharma, K Kalia, RK Tekade - Acta biomaterialia, 2020 - Elsevier
Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

The cell cycle, cancer development and therapy

E Jamasbi, M Hamelian, MA Hossain… - Molecular biology reports, 2022 - Springer
The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …

Anticancer properties of essential oils and other natural products

K Blowman, M Magalhães, MFL Lemos… - Evidence‐Based …, 2018 - Wiley Online Library
Essential oils are secondary metabolites with a key‐role in plants protection, consisting
primarily of terpenes with a volatile nature and a diverse array of chemical structures …

[HTML][HTML] Exploring the potent anticancer activity of essential oils and their bioactive compounds: Mechanisms and prospects for future cancer therapy

F Mohamed Abdoul-Latif, A Ainane… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide, affecting millions of people each
year. Fortunately, the last decades have been marked by considerable advances in the field …

The ferric reducing/antioxidant power (FRAP) assay for non‐enzymatic antioxidant capacity: concepts, procedures, limitations and applications

IFF Benzie, M Devaki - … of antioxidant activity & capacity: Recent …, 2018 - Wiley Online Library
This chapter presents concepts, technical tips and calculations, along with some illustrative
examples of how the ferric reducing/antioxidant power (FRAP) assay has been applied in …

Genetic etiology of oral cancer

J Ali, B Sabiha, HU Jan, SA Haider, AA Khan, SS Ali - Oral oncology, 2017 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. It accounts for 2.5% of all new cancer cases and 1.9% of all cancer deaths …