T-Type calcium channels: a mixed blessing
The role of T-type calcium channels is well established in excitable cells, where they preside
over action potential generation, automaticity, and firing. They also contribute to intracellular …
over action potential generation, automaticity, and firing. They also contribute to intracellular …
Anti-leishmanial therapies: overcoming current challenges with emerging therapies
Introduction Leishmaniasis, including visceral, cutaneous, and mucocutaneous forms,
present a major health challenge in tropical regions. Current antileishmanial medications …
present a major health challenge in tropical regions. Current antileishmanial medications …
Using ChEMBL to complement schistosome drug discovery
G Padalino, A Coghlan, G Pagliuca, JE Forde-Thomas… - Pharmaceutics, 2023 - mdpi.com
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni
Proteases are fundamental to successful parasitism, including that of the schistosome
flatworm parasite, which causes the disease schistosomiasis in 200 million people …
flatworm parasite, which causes the disease schistosomiasis in 200 million people …
[HTML][HTML] Identification of new drug candidates against Trichomonas gallinae using high-throughput screening
S **g, Q Zhang, Y Li, H Chang, C ** at host's body temperature
Fasciola hepatica is a global parasite of livestock which also causes a neglected zoonosis in
humans. The parasite's communication with the host during its complicated lifecycle is …
humans. The parasite's communication with the host during its complicated lifecycle is …
Transcriptome-Wide Comparisons and Virulence Gene Polymorphisms of Host-Associated Genotypes of the Cnidarian Parasite Ceratonova shasta in Salmonids
Ceratonova shasta is an important myxozoan pathogen affecting the health of salmonid
fishes in the Pacific Northwest of North America. Ceratonova shasta exists as a complex of …
fishes in the Pacific Northwest of North America. Ceratonova shasta exists as a complex of …
Investigational new drugs for the treatment of leishmaniasis
Introduction Over the past 20 years, significant progress has been made in anti-leishmanial
therapy. Three new drugs/formulations are available for the treatment of various forms of …
therapy. Three new drugs/formulations are available for the treatment of various forms of …
[HTML][HTML] Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni
TB Duguet, A Glebov, A Hussain, S Kulkarni… - International Journal for …, 2020 - Elsevier
Neglected tropical diseases are of growing worldwide concern and schistosomiasis, caused
by parasitic flatworms, continues to be a major threat with more than 200 million people …
by parasitic flatworms, continues to be a major threat with more than 200 million people …
Dealing with schistosomiasis: Current drug discovery strategies
Schistosomiasis is one of the most prevalent parasitic diseases, accounting for heavy
socioeconomical and health burden in endemic countries. The control of this neglected …
socioeconomical and health burden in endemic countries. The control of this neglected …