The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate
balance and producing hormones. Its development during childhood determines height and …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Injectable hydrogel is suitable for the repair of lacunar bone deficiency. This study fabricated
an injectable, self-adaptive silk fibroin/mesoporous bioglass/sodium alginate (SMS) …

The importance of matrix vesicles (MVs) has been repeatedly highlighted in the formation of
cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures …

Cushing's syndrome (CS) is a severe condition that results from chronic exposure to
elevated circulating cortisol levels; it is a rare but potentially life-threating condition …

Autophagy is an evolutionarily conserved intracellular process and is considered one of the
main catabolism pathways. In the process of autophagy, cells are digested nonselectively or …

An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …