Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …

Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours,,–, but the
cause of this link is unknown. Here we show that tumour cells disrupt methionine …

The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are
incompletely understood. We report that cholesterol in the tumor microenvironment induces …

Current immunotherapies yield remarkable clinical outcomes by boosting the power of host
immunity in cancer cell elimination and viral clearance. However, after prolonged antigen …

Chronic inflammation triggers compensatory immunosuppression to stop inflammation and
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …