Cancer stem cells: A review from origin to therapeutic implications
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …
MicroRNA as biomarkers and diagnostics
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …
a range of developmental and physiological processes; their dysregulation has been …
The multifaceted functions of sirtuins in cancer
A Chalkiadaki, L Guarente - Nature Reviews Cancer, 2015 - nature.com
The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …
that regulate a large number of cellular pathways and forestall the progression of ageing …
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Members of the miR-34 family are induced by the tumor suppressor p53 and are known to
inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the …
inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the …
[HTML][HTML] MicroRNA and cancer
With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …
MicroRNAs: history, biogenesis, and their evolving role in animal development and disease
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …
in small RNA biology have redefined the biological landscape by significantly altering the …
MicroRNA as an important target for anticancer drug development
Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …
several different classes of anticancer drugs that are available in clinic, some tough issues …
MicroRNAome genome: a treasure for cancer diagnosis and therapy
The interplay between abnormalities in genes coding for proteins and noncoding
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …
Alternative mechanisms of miR-34a regulation in cancer
MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
The biological functions of miRNAs: lessons from in vivo studies
Despite their clear importance as a class of regulatory molecules, pinpointing the relevance
of individual miRNAs has been challenging. Studies querying miRNA functions by …
of individual miRNAs has been challenging. Studies querying miRNA functions by …