Background: Observations play a pivotal role in the progress of science, including in
pathology. The cause of a disease such as cancer is analyzed by breaking it down into …

The management of patients with Central Nervous System (CNS) malignancies relies on the
appropriate classification of these tumors. Recently, the World Health Organization (WHO) …

Extraneural metastases of glioblastoma (GBM), although rare, are becoming an increasingly
recognized occurrence. Currently, the biological mechanism underlying this rare occurrence …

Simple Summary Glioblastoma multiforme (GBM) is a highly invasive brain tumor that
typically has poor patient outcomes. This is due in part to aggressive tumor expansion within …

Pediatric brain tumors are an incredibly diverse group of neoplasms and neuropathological
tumor classification is an essential part of patient care. Classification of pediatric brain …

PURPOSE Molecular characterization is key to optimally diagnose and manage cancer. The
complexity and cost of routine genomic analysis have unfortunately limited its use and …

Simple Summary TP53 is a tumor-suppressor gene that is involved in cell cycle arrest, and
its mutation is an event that is recognized to cause and contribute to carcinogenesis …

Purpose TP53 is the most frequently mutated gene in gastric cancer and it can be potentially
used for gastric cancer diagnosis and screening. However, standardized clinical …

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been
classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations …

Medulloblastoma is a rare brain tumor that occurs in both children and adults, with patients
aged 15 to 39 years accounting for 30% of all cases. In adults, guidelines for diagnosis and …