HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis

PRD Murray, JH Cox, ND Chiappini, CB Roos… - Chemical …, 2021 - ACS Publications
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

Construction of C–N bonds from small-molecule precursors through heterogeneous electrocatalysis

J Li, Y Zhang, K Kuruvinashetti… - Nature Reviews Chemistry, 2022 - nature.com
Energy-intensive thermochemical processes within chemical manufacturing are a major
contributor to global CO2 emissions. With the increasing push for sustainability, the scientific …

Electrochemical oxidative cross-coupling with hydrogen evolution reactions

Y Yuan, A Lei - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Oxidative cross-coupling has proved to be one of the most straightforward
strategies for forming carbon–carbon and carbon–heteroatom bonds from easily available …

High electric field on water microdroplets catalyzes spontaneous and ultrafast oxidative C–H/N–H cross-coupling

D Zhang, X Yuan, C Gong, X Zhang - Journal of the American …, 2022 - ACS Publications
Oxidative C–H/N–H cross-coupling has emerged as an atom-economical method for the
construction of C–N bonds. Conventional oxidative C–H/N–H coupling requires at least one …

Catalytic electrophilic halogenation of arenes with electron-withdrawing substituents

W Wang, X Yang, R Dai, Z Yan, J Wei… - Journal of the …, 2022 - ACS Publications
The electrophilic halogenation of arenes is perhaps the simplest method to prepare aryl
halides, which are important structural motifs in agrochemicals, materials, and …

[HTML][HTML] Electrochemical generation of nitrogen-centered radicals for organic synthesis

N Chen, HC Xu - Green Synthesis and Catalysis, 2021 - Elsevier
There is a resurgence of interests in organic electrochemistry, which is generally accepted
as a green synthetic tool. In this context, many electrochemical methods have been …

Organic electrosynthesis: applications in complex molecule synthesis

A Shatskiy, H Lundberg, MD Kärkäs - ChemElectroChem, 2019 - Wiley Online Library
Organic electrosynthesis is an enabling and sustainable technology, which constitutes a
rapidly expanding field of research. Electrochemical approaches serve as convenient and …

Aqueous pulsed electrochemistry promotes C− N bond formation via a one-pot cascade approach

M He, Y Wu, R Li, Y Wang, C Liu, B Zhang - Nature Communications, 2023 - nature.com
Electrocatalytic C− N bond formation from inorganic nitrogen wastes is an emerging
sustainable method for synthesizing organic amines but is limited in reaction scope …

Insertion of ammonia into alkenes to build aromatic N-heterocycles

S Liu, X Cheng - Nature Communications, 2022 - nature.com
Ammonia is one of the most abundant and simple nitrogen sources with decent stability and
reactivity. Direct insertion of ammonia into a carbon skeleton is an ideal approach to building …