Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …
due to altered antibody evasion properties deriving from their additional spike mutations …
Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
Characterization of the enhanced infectivity and antibody evasion of Omicron BA. 2.75
Summary Recently emerged SARS-CoV-2 Omicron subvariant, BA. 2.75, displayed a growth
advantage over circulating BA. 2.38, BA. 2.76, and BA. 5 in India. However, the underlying …
advantage over circulating BA. 2.38, BA. 2.76, and BA. 5 in India. However, the underlying …
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines
JE Bowen, YJ Park, C Stewart, JT Brown… - Science …, 2022 - science.org
Numerous safe and effective coronavirus disease 2019 vaccines have been developed
worldwide that use various delivery technologies and engineering strategies. We show here …
worldwide that use various delivery technologies and engineering strategies. We show here …
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB. 1.5 mRNA booster in humans
Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking
SARS-CoV-2 continues to evolve, with many variants evading clinically authorized
antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities …
antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities …
Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN. 1 sublineages
The recently dominant SARS-CoV-2 Omicron JN. 1 has evolved into multiple sublineages,
with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth …
with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth …