Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

Inorganic polyphosphate (polyP), the first high-energy compound on earth, defies its
extreme compositional and structural simplicity with an astoundingly wide array of biological …

Abstract α-Synuclein (α-syn), as a primary pathogenic protein in Parkinson's disease (PD)
and other synucleinopathies, exhibits a high potential to form polymorphic fibrils. Chemical …

Amyloid fibrillar assemblies, originally identified as pathological entities in
neurodegenerative diseases, have been widely adopted by various proteins to fulfill diverse …

The dense neuropil of the central nervous system leaves only limited space for extracellular
substances free. The advent of immunohistochemistry, soon followed by advanced …

The synucleinopathies, which include Parkinson's disease, dementia with Lewy bodies, and
multiple system atrophy, are a class of human neurodegenerative disorders unified by the …