Platelet physiology

T Gremmel, AL Frelinger III… - Seminars in thrombosis …, 2016 - thieme-connect.com
Platelets are the smallest blood cells, numbering 150 to 350× 10 9/L in healthy individuals.
The ability of activated platelets to adhere to an injured vessel wall and form aggregates was …

[HTML][HTML] Platelet‐based coagulation: different populations, different functions

JWM Heemskerk, NJA Mattheij, J Cosemans - Journal of Thrombosis and …, 2013 - Elsevier
Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease

Z Liu, RA Khalil - Biochemical pharmacology, 2018 - Elsevier
Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Platelet secretion in inflammatory and infectious diseases

BK Manne, SC **ang, MT Rondina - Platelets, 2017 - Taylor & Francis
Platelets are small, anucleate circulating cells that possess a dynamic repertoire of functions
spanning the hemostatic, inflammatory, and immune continuum. Once thought to be merely …

Dual regulation of glycogen synthase kinase 3 (GSK3) α/β by protein kinase C (PKC) α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule …

SF Moore, MTJ van den Bosch, RW Hunter… - Journal of Biological …, 2013 - ASBMB
Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited
by phosphorylation of an N-terminal Ser residue (Ser 21 in GSK3α and Ser 9 in GSK3β) in …

Measurement of whole blood thrombus formation using parallel-plate flow chambers–a practical guide

R Van Kruchten, JMEM Cosemans, JWM Heemskerk - Platelets, 2012 - Taylor & Francis
Custom-made and commercial parallel-plate flow chambers are widely used for studies of
platelet activation and thrombus formation in whole blood at defined shear rates. When used …

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

F Beck, J Geiger, S Gambaryan… - Blood, The Journal …, 2017 - ashpublications.org
Adenosine diphosphate (ADP) enhances platelet activation by virtually any other stimulant
to complete aggregation. It binds specifically to the G-protein–coupled membrane receptors …

Protein kinase C as regulator of vascular smooth muscle function and potential target in vascular disorders

HC Ringvold, RA Khalil - Advances in pharmacology, 2017 - Elsevier
Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In
addition to Ca 2+-dependent myosin light chain (MLC) phosphorylation, protein kinase C …

Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets

NJA Mattheij, K Gilio, R van Kruchten, SM Jobe… - Journal of Biological …, 2013 - ASBMB
Aggregation of platelets via activated integrin α IIb β 3 is a prerequisite for thrombus
formation. Phosphatidylserine-exposing platelets with a key role in the coagulation process …

Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine

WD Jiang, K Hu, JX Zhang, Y Liu, J Jiang… - British Journal of …, 2015 - cambridge.org
This study investigated the effects of glycinin on the growth, intestinal oxidative status, tight
junction components, cytokines and apoptosis signalling factors of fish. The results showed …