Abstract Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive
loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

High carbohydrate diet (HCD) causes metabolism disorder and intestinal damages in
aquaculture fish. Berberine has been applied to improve obesity, diabetes and NAFLD …

β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …

Pancreatic beta-cell death has been established as a critical mediator in the progression of
type 1 and type 2 diabetes mellitus. Beta-cell death is associated with exacerbating …

Diabetes is a metabolic disease characterized by high blood glucose levels. With economic
development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it …

Abstract Objective Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell
loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β …

Renal interstitial fibrosis (RIF) is a significant pathological change in diabetic kidney disease
(DKD) that can be induced by endothelial-to-mesenchymal transition (EndMT) …

Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones,
can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in …