Oral cancer is one of the most leading cancer responsible for significant morbidity and
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

In mammals, seven members of the sirtuin protein family known as class III histone
deacetylase have been identified for their characteristic features. These distinguished …

Abstract Sirtuins 1‐7 (SIRT1‐7) belong to the third class of deacetylase enzymes, which are
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …

Abstract Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target
mitochondrial proteins for lysine deacetylation and also regulate cellular functions. And …

The first link between sirtuins and longevity was made 15 years ago in yeast. These initial
studies sparked efforts by many laboratories working in diverse model organisms to …

The use of small antimicrobial peptides or bacteriocins, like nisin, to treat cancer is a new
approach that holds great promise. Nisin exemplifies this new approach because it has …

Abstract Sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, targets
various mitochondrial proteins for lysine deacetylation and regulates important cellular …