Facts and hopes in immunotherapy of endometrial cancer

JA Marín-Jiménez, S García-Mulero, X Matías-Guiu… - Clinical Cancer …, 2022 - AACR
Immunotherapy with checkpoint inhibitors has changed the paradigm of treatment for many
tumors, and endometrial carcinoma is not an exception. Approved treatment options are …

Molecular subtypes of endometrial cancer: Implications for adjuvant treatment strategies

Y Yang, SF Wu, W Bao - International Journal of Gynecology & …, 2024 - Wiley Online Library
Background When determining adjuvant treatment for endometrial cancer, the decision
typically relies on factors such as cancer stage, histologic grade, subtype, and a few …

IgA-dominated humoral immune responses govern patients' outcome in endometrial cancer

G Mandal, S Biswas, CM Anadon, X Yu, CD Gatenbee… - Cancer research, 2022 - AACR
Recent studies suggest that B cells could play an important role in the tumor
microenvironment. However, the role of humoral responses in endometrial cancer remains …

Endometrial carcinoma: immune microenvironment and emerging treatments in immuno-oncology

S Rousset-Rouviere, P Rochigneux, AS Chretien… - Biomedicines, 2021 - mdpi.com
Endometrial cancer (EC) can easily be cured when diagnosed at an early stage. However,
advanced and metastatic EC is a common disease, affecting more than 15,000 patients per …

Immune checkpoint inhibitors and mismatch repair status in advanced endometrial cancer: elective affinities

A Rizzo - Journal of clinical medicine, 2022 - mdpi.com
Since endometrial cancers (ECs) are frequently TMB-H and MSI-H/dMMR tumors, this
element has provided the rationale for testing immune checkpoint inhibitors (ICIs), which …

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors

I Salewski, J Henne, L Engster, P Krone… - …, 2022 - Taylor & Francis
Mismatch repair-deficient (dMMR) tumors show a good response toward immune checkpoint
inhibitors (ICI), but develo** resistance impairs patients' outcomes. Here, we compared …

Inflammation-related LncRNAs signature for prognosis and immune response evaluation in uterine corpus endometrial carcinoma

H Gu, J Song, Y Chen, Y Wang, X Tan, H Zhao - Frontiers in oncology, 2022 - frontiersin.org
Backgrounds Uterine corpus endometrial carcinoma (UCEC) is one of the greatest threats
on the female reproductive system. The aim of this study is to explore the inflammation …

Importance of the endometrial immune environment in endometrial cancer and associated therapies

H van der Woude, KE Hally, MJ Currie, O Gasser… - Frontiers in …, 2022 - frontiersin.org
Endometrial cancer is rising in prevalence. The standard treatment modality of hysterectomy
is becoming increasingly inadequate due primarily to the direct link between endometrial …

The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma

X Liu, H Ma, L Ma, K Li, Y Kang - Bioengineered, 2022 - Taylor & Francis
To explore the potential function of methyltransferase-like 5 (METTL5) in uterine corpus
endometrial carcinoma (UCEC) and verify the relationship between deficient DNA mismatch …

ImmuneScore of eight-gene signature predicts prognosis and survival in patients with endometrial cancer

J Gu, Z Wang, BO Wang, X Ma - Frontiers in Oncology, 2023 - frontiersin.org
Background Endometrial cancer (EC) is a common gynecological cancer worldwide and the
sixth most common female malignant tumor. A large number of studies conducted through …