Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …
have modified their virulence mechanisms to adapt to host defense systems. Although the …
Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes
JR Huddleston - Infection and drug resistance, 2014 - Taylor & Francis
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic
resistance among pathogens. This review aims to give an overview of the major horizontal …
resistance among pathogens. This review aims to give an overview of the major horizontal …
Selection of resistant bacteria at very low antibiotic concentrations
The widespread use of antibiotics is selecting for a variety of resistance mechanisms that
seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected …
seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected …
Antibiotic resistance and its cost: is it possible to reverse resistance?
Most antibiotic resistance mechanisms are associated with a fitness cost that is typically
observed as a reduced bacterial growth rate. The magnitude of this cost is the main …
observed as a reduced bacterial growth rate. The magnitude of this cost is the main …
Potential impacts of disinfection processes on elimination and deactivation of antibiotic resistance genes during water and wastewater treatment
MC Dodd - Journal of Environmental Monitoring, 2012 - pubs.rsc.org
Antibiotic resistance genes (ARGs), in association with antibiotic resistant bacteria (ARB),
have been identified as widespread contaminants of treated drinking waters and …
have been identified as widespread contaminants of treated drinking waters and …
High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung Infection
The lungs of cystic fibrosis (CF) patients are chronically infected for years by one or a few
lineages of Pseudomonas aeruginosa. These bacterial populations adapt to the highly …
lineages of Pseudomonas aeruginosa. These bacterial populations adapt to the highly …
Evolutionary trajectories to antibiotic resistance
The ability to predict the evolutionary trajectories of antibiotic resistance would be of great
value in tailoring dosing regimens of antibiotics so as to maximize the duration of their …
value in tailoring dosing regimens of antibiotics so as to maximize the duration of their …
Persistence of antibiotic resistance in bacterial populations
Unfortunately for mankind, it is very likely that the antibiotic resistance problem we have
generated during the last 60 years due to the extensive use and misuse of antibiotics is here …
generated during the last 60 years due to the extensive use and misuse of antibiotics is here …
Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli
ZD Blount, CZ Borland… - Proceedings of the …, 2008 - National Acad Sciences
The role of historical contingency in evolution has been much debated, but rarely tested.
Twelve initially identical populations of Escherichia coli were founded in 1988 to investigate …
Twelve initially identical populations of Escherichia coli were founded in 1988 to investigate …
Mutation frequencies and antibiotic resistance
Antibiotic resistance can be achieved by horizontal acquisition of resistance genes (carried
by plasmids or transposons), by recombination of foreign DNA into the chromosome, or by …
by plasmids or transposons), by recombination of foreign DNA into the chromosome, or by …