The cell biology of ferroptosis

SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

A guideline on the molecular ecosystem regulating ferroptosis

E Dai, X Chen, A Linkermann, X Jiang, R Kang… - Nature cell …, 2024 - nature.com
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual Review of …, 2023 - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Mechanisms and regulations of ferroptosis

XD Zhang, ZY Liu, MS Wang, YX Guo… - Frontiers in …, 2023 - frontiersin.org
Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

X Yang, Z Wang, SN Samovich, AA Kapralov… - Cell Metabolism, 2024 - cell.com
Although the role of ferroptosis in killing tumor cells is well established, recent studies
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Vitamin K: New insights related to senescence and cancer metastasis

A Chen, J Li, N Shen, H Huang, Q Hang - Biochimica et Biophysica Acta …, 2024 - Elsevier
Several clinical trials and experimental studies have recently shown that vitamin K (VK)
supplementation benefits the human body. Specifically, VK participates in coagulation and is …

Gut microbial metabolism in ferroptosis and colorectal cancer

W Cui, M Hao, X Yang, C Yin, B Chu - Trends in Cell Biology, 2024 - cell.com
Ferroptosis is programmed cell death induced by iron-driven lipid peroxidation. Numerous
studies have shown that ferroptosis is implicated in the progression of colorectal cancer …