The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
Lipid quality control and ferroptosis: from concept to mechanism
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies
Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …
Mechanisms and regulations of ferroptosis
XD Zhang, ZY Liu, MS Wang, YX Guo… - Frontiers in …, 2023 - frontiersin.org
Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …
is an iron-dependent regulated cell death whose mechanism has been extensively studied …
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Although the role of ferroptosis in killing tumor cells is well established, recent studies
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …
The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …
Vitamin K: New insights related to senescence and cancer metastasis
A Chen, J Li, N Shen, H Huang, Q Hang - Biochimica et Biophysica Acta …, 2024 - Elsevier
Several clinical trials and experimental studies have recently shown that vitamin K (VK)
supplementation benefits the human body. Specifically, VK participates in coagulation and is …
supplementation benefits the human body. Specifically, VK participates in coagulation and is …
Gut microbial metabolism in ferroptosis and colorectal cancer
Ferroptosis is programmed cell death induced by iron-driven lipid peroxidation. Numerous
studies have shown that ferroptosis is implicated in the progression of colorectal cancer …
studies have shown that ferroptosis is implicated in the progression of colorectal cancer …