Measuring disease severity in inflammatory bowel disease–Beyond treat to target

A Swaminathan, AS Day, MP Sparrow… - Alimentary …, 2024 - Wiley Online Library
Background Inflammatory bowel disease (IBD) follows a heterogenous disease course and
predicting a patient's prognosis is challenging. There is a wide burden of illness in IBD and …

The future of precision medicine to predict outcomes and control tissue remodeling in inflammatory bowel disease

CA Lamb, A Saifuddin, N Powell, F Rieder - Gastroenterology, 2022 - Elsevier
Inflammatory bowel disease is characterized by significant interindividual heterogeneity.
With a wider selection of pharmacologic and nonpharmacologic interventions available and …

Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis

Z Wei, S Hang, DK Wiredu Ocansey, Z Zhang… - Journal of …, 2023 - Springer
Background Ferroptosis, a unique form of non-apoptotic cell death, is dependent on iron and
lipoperoxidation, and has been shown to be associated with the pathogenesis of …

Digital health technologies for remote monitoring and management of inflammatory bowel disease: a systematic review

NH Nguyen, I Martinez, A Atreja… - Official journal of the …, 2022 - journals.lww.com
METHODS: Through a systematic review of multiple databases through August 31, 2020, we
identified randomized controlled trials in patients with IBD comparing digital health …

Artificial intelligence in inflammatory bowel disease endoscopy: implications for clinical trials

HA Ahmad, JE East, R Panaccione… - Journal of Crohn's …, 2023 - academic.oup.com
Artificial intelligence shows promise for clinical research in inflammatory bowel disease
endoscopy. Accurate assessment of endoscopic activity is important in clinical practice and …

[HTML][HTML] Integrating evidence to guide use of biologics and small molecules for inflammatory bowel diseases

PS Dulai, S Singh, V Jairath, E Wong, N Narula - Gastroenterology, 2024 - Elsevier
Advances in science have led to the development of multiple biologics and small molecules
for the treatment of inflammatory bowel diseases (IBDs). This growth in advanced medical …

Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease

C Ma, V Jairath, BG Feagan, L Peyrin-Biroulet… - Nature Reviews …, 2024 - nature.com
Abstract Treatment options for the medical management of inflammatory bowel disease
(IBD) have expanded substantially over the past decade. Multiple classes of advanced …

Personalized (N-of-1) clinical trials for inflammatory bowel disease: opportunities and challenges

S Honap, G Zou, S Danese, L Peyrin-Biroulet… - Clinical …, 2024 - Elsevier
Abstract Background and Aims Heterogeneity of treatment effects in inflammatory bowel
disease means that many individuals or patient subgroups depart from the average for …

Artificial intelligence and endo-histo-omics: new dimensions of precision endoscopy and histology in inflammatory bowel disease

M Iacucci, G Santacroce, I Zammarchi… - The Lancet …, 2024 - thelancet.com
Integrating artificial intelligence into inflammatory bowel disease (IBD) has the potential to
revolutionise clinical practice and research. Artificial intelligence harnesses advanced …

Screening failure in a large clinical trial centre for inflammatory bowel diseases: rates, causes, and outcomes

A Outtier, L Gijbels, M Noman… - Inflammatory Bowel …, 2023 - academic.oup.com
Background Patients with inflammatory bowel diseases (IBD) sometimes require
investigational medicinal therapy in a clinical trial. Before enrollment, patients must meet …