BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …

Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Recurrent spontaneous abortion (RSA) is defined as two or more pregnancy loss, affecting
the happiness index of fertility couples. The mechanisms involved in the occurrence of RSA …

The immune response upon infection with the pathogen Mycobacterium tuberculosis is
poorly understood, hampering the discovery of new treatments and the improvements in …

Tuberculosis (TB) and depression act synergistically via social, behavioral, and biological
mechanisms to magnify the burden of disease. Clinical depression is a common, under …

Although tuberculosis (TB) causes more deaths than any other pathogen, most infected
individuals harbor the pathogen without signs of disease. We explored the metabolome of> …

Initially, indoleamine-2, 3-dioxygenase (IDO) has been introduced as a bactericidal effector
mechanism and has been linked to T-cell immunosuppression and tolerance. In recent …

The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading
to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and …

Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage
polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates …