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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
The medial prefrontal cortex-hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical …
OY Chao, MA de Souza Silva, YM Yang… - … & Biobehavioral Reviews, 2020 - Elsevier
Rats and mice have been demonstrated to show episodic-like memory, a prototype of
episodic memory, as defined by an integrated memory of the experience of an object or …
episodic memory, as defined by an integrated memory of the experience of an object or …
Hippocampal neurogenesis: learning to remember
O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
Higher body mass index is associated with episodic memory deficits in young adults
Obesity has become an international health crisis. There is accumulating evidence that
excess bodyweight is associated with changes to the structure and function of the brain and …
excess bodyweight is associated with changes to the structure and function of the brain and …
Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Background Communication between the gut microbiota and the brain is primarily mediated
via soluble microbe-derived metabolites, but the details of this pathway remain poorly …
via soluble microbe-derived metabolites, but the details of this pathway remain poorly …
Early-onset network hyperexcitability in presymptomatic Alzheimer's disease transgenic mice is suppressed by passive immunization with anti-human APP/Aβ …
Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Challenges and advanced concepts for the assessment of learning and memory function in mice
The mechanisms underlying the formation and retrieval of memories are still an active area
of research and discussion. Manifold models have been proposed and refined over the …
of research and discussion. Manifold models have been proposed and refined over the …
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease
SF Kazim, K Iqbal - Molecular neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is an incurable and debilitating chronic progressive
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …
Episodic-like memory is preserved with age in cuttlefish
Episodic memory, remembering past experiences based on unique what–where–when
components, declines during ageing in humans, as does episodic-like memory in non …
components, declines during ageing in humans, as does episodic-like memory in non …