Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

SJ Webster, AD Bachstetter, PT Nelson… - Frontiers in …, 2014 - frontiersin.org
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

The medial prefrontal cortex-hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical …

OY Chao, MA de Souza Silva, YM Yang… - … & Biobehavioral Reviews, 2020 - Elsevier
Rats and mice have been demonstrated to show episodic-like memory, a prototype of
episodic memory, as defined by an integrated memory of the experience of an object or …

Hippocampal neurogenesis: learning to remember

O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …

Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau

SF Kazim, JH Seo, R Bianchi, CS Larson, A Sharma… - Eneuro, 2021 - eneuro.org
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …

Higher body mass index is associated with episodic memory deficits in young adults

LG Cheke, JS Simons… - Quarterly Journal of …, 2016 - journals.sagepub.com
Obesity has become an international health crisis. There is accumulating evidence that
excess bodyweight is associated with changes to the structure and function of the brain and …

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

L Hoyles, MG Pontifex, I Rodriguez-Ramiro… - Microbiome, 2021 - Springer
Background Communication between the gut microbiota and the brain is primarily mediated
via soluble microbe-derived metabolites, but the details of this pathway remain poorly …

Early-onset network hyperexcitability in presymptomatic Alzheimer's disease transgenic mice is suppressed by passive immunization with anti-human APP/Aβ …

SF Kazim, SC Chuang, W Zhao, RKS Wong… - Frontiers in aging …, 2017 - frontiersin.org
Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …

Challenges and advanced concepts for the assessment of learning and memory function in mice

B Lang, P Kahnau, K Hohlbaum, P Mieske… - Frontiers in Behavioral …, 2023 - frontiersin.org
The mechanisms underlying the formation and retrieval of memories are still an active area
of research and discussion. Manifold models have been proposed and refined over the …

Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease

SF Kazim, K Iqbal - Molecular neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is an incurable and debilitating chronic progressive
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …

Episodic-like memory is preserved with age in cuttlefish

AK Schnell, NS Clayton… - Proceedings of the …, 2021 - royalsocietypublishing.org
Episodic memory, remembering past experiences based on unique what–where–when
components, declines during ageing in humans, as does episodic-like memory in non …