Prediction of peptide mass spectral libraries with machine learning

J Cox - Nature Biotechnology, 2023 - nature.com
The recent development of machine learning methods to identify peptides in complex mass
spectrometric data constitutes a major breakthrough in proteomics. Longstanding methods …

Alternative tumour-specific antigens

CC Smith, SR Selitsky, S Chai, PM Armistead… - Nature Reviews …, 2019 - nature.com
The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has
accelerated within the past decade. The most commonly studied class of TSAs are those …

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Y Perez-Riverol, J Bai, C Bandla… - Nucleic acids …, 2022 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data. PRIDE is …

The ProteomeXchange consortium in 2020: enabling 'big data'approaches in proteomics

EW Deutsch, N Bandeira, V Sharma… - Nucleic acids …, 2020 - academic.oup.com
The ProteomeXchange (PX) consortium of proteomics resources (http://www.
proteomexchange. org) has standardized data submission and dissemination of mass …

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Y Perez-Riverol, A Csordas, J Bai… - Nucleic acids …, 2019 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data, and is one …

MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics

AT Kong, FV Leprevost, DM Avtonomov… - Nature …, 2017 - nature.com
There is a need to better understand and handle the'dark matter'of proteomics—the vast
diversity of post-translational and chemical modifications that are unaccounted in a typical …

Beyond mass spectrometry, the next step in proteomics

W Timp, G Timp - Science Advances, 2020 - science.org
Proteins can be the root cause of a disease, and they can be used to cure it. The need to
identify these critical actors was recognized early (1951) by Sanger; the first biopolymer …

Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine

H Chi, C Liu, H Yang, WF Zeng, L Wu, WJ Zhou… - Nature …, 2018 - nature.com
We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an
ultra-large search space that includes coeluting peptides, unexpected modifications and …

Identification of small molecules using accurate mass MS/MS search

T Kind, H Tsugawa, T Cajka, Y Ma, Z Lai… - Mass spectrometry …, 2018 - Wiley Online Library
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS
spectra from screening small molecules in fields such as environmental analysis, drug …

Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction

NS Nurmohamed, JM Kraaijenhof, M Mayr… - European heart …, 2023 - academic.oup.com
Given the limited accuracy of clinically used risk scores such as the Systematic COronary
Risk Evaluation 2 system and the Second Manifestations of ARTerial disease 2 risk scores …